Design, Activity, and 2.8 Å Crystal Structure of a C 2 Symmetric Inhibitor Complexed to HIV-1 Protease-Reference-Cited by-同舟云学术

Design, Activity, and 2.8 Å Crystal Structure of a C 2 Symmetric Inhibitor Complexed to HIV-1 Protease

Published:1990-08-03 Issue:4968 Volume:249 Page:527-533
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Erickson John¹,Neidhart David J.¹,VanDrie John²,Kempf Dale J.³,Wang Xiu Chun³,Norbeck Daniel W.³,Plattner Jacob J.³,Rittenhouse Judith W.³,Turon Mary³,Wideburg Norman³,Kohlbrenner William E.³,Simmer Robert⁴,Helfrich Rosalind⁴,Paul Deborah A.⁵,Knigge Mark⁵

Affiliation:

1. Department of Computer-Assisted Molecular Design, Abbott Laboratories, Abbott Park, IL 60064.

2. Meridien Research, Oak Park, IL 60303.

3. Department of Anti-Infectives Research, Abbott Laboratories, Abbott Park, IL 60064.

4. Department of Molecular and Cellular Biology, Abbott Laboratories, Abbott Park, IL 60064.

5. Department of Hepatitis/AIDS Research, Abbott Laboratories, North Chicago, IL 60064.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference41 articles.

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2. CRAWFORD, S, A DELETION MUTATION IN THE 5' PART OF THE POL GENE OF MOLONEY MURINE LEUKEMIA-VIRUS BLOCKS PROTEOLYTIC PROCESSING OF THE GAG AND POL POLYPROTEINS, JOURNAL OF VIROLOGY 53: 899 (1985).

3. DREYER, G.B., INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE INVITRO - RATIONAL DESIGN OF SUBSTRATE-ANALOG INHIBITORS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 9752 (1989).

4. ERICKSON, J, VIRAL PROTTEINASES T: 191 (1989).

5. FITZGERALD, PMD, J APPL CRYSTALLOGR 21: 53 (1988).

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