Effect of soluble oat fiber on intestinal microenvironment and TNBS-induced colitis

Author:

Chudan Seita1,Ishibashi Riko2,Nishikawa Miyu1,Tabuchi Yoshiaki3ORCID,Nagai Yoshinori2,Ikushiro Shinichi1ORCID,Furusawa Yukihiro23ORCID

Affiliation:

1. Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Kurokawa, Toyama 939-0398, Japan

2. Department of Pharmaceutical Engineering, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Toyama 939-0398, Japan

3. Division of Molecular Genetics Research, Life Science Research Center, University of Toyama, Sugitani, Toyama 930-0194, Japan

Abstract

Soluble oat fiber increased colonic butyrate, peripherally-induced Treg cells and thus alleviated TNBS-induced colitis, which coincided with overrepresentation of F. rodentium (a human analog of H. biformis) possessing butyrate-producing metagenomes.

Funder

Japan Society for the Promotion of Science

Lotte Foundation

Tamura Science and Technology Foundation

Takeda Science Foundation

Tojuro Iijima Foundation for Food Science and Technology

Kanamori Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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