Bi- to tetravalent glycoclusters presenting GlcNAc/GalNAc as inhibitors: from plant agglutinins to human macrophage galactose-type lectin (CD301) and galectins-Reference-Cited by-同舟云学术

Bi- to tetravalent glycoclusters presenting GlcNAc/GalNAc as inhibitors: from plant agglutinins to human macrophage galactose-type lectin (CD301) and galectins

Published:2015 Issue:14 Volume:13 Page:4190-4203
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

André Sabine¹²³⁴⁵,O'Sullivan Shane⁶⁷⁸⁹,Koller Christiane¹²³⁴⁵,Murphy Paul V.⁶⁷⁸⁹,Gabius Hans-Joachim¹²³⁴⁵

Affiliation:

1. Institute of Physiological Chemistry

2. Faculty of Veterinary Medicine

3. Ludwig-Maximilians-University Munich

4. 80539 Munich

5. Germany

6. School of Chemistry

7. National University of Ireland Galway

8. Galway

9. Ireland

Abstract

The trimeric C-type lectin MGL is involved in activating immune defence and virus uptake, thus becoming a target for inhibitor design. A tetravalent cluster with α-S-GalNAc proved to be effective in the nM range.

Funder

Science Foundation Ireland

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00048C

Reference96 articles.

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4. Endothelial heterogeneity and adhesion molecules N-glycosylation: Implications in leukocyte trafficking in inflammation

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