MUC1 Glycopeptide Vaccine Modified with a GalNAc Glycocluster Targets the Macrophage Galactose C-type Lectin on Dendritic Cells to Elicit an Improved Humoral Response

Author:

Gabba Adele12ORCID,Attariya Riem3,Behren Sandra4,Pett Christian4,van der Horst Joost C.56,Yurugi Hajime3,Yu Jin7,Urschbach Moritz2,Sabin Juan89,Birrane Gabriel10ORCID,Schmitt Edgar3,van Vliet Sandra J.56,Besenius Pol2ORCID,Westerlind Ulrika4,Murphy Paul V.111ORCID

Affiliation:

1. School of Biological and Chemical Sciences, University of Galway, University Rd., H91 TK33 Galway, Ireland

2. Department of Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10−14, 55128 Mainz, Germany

3. Institute of Immunology, University Medical Center Mainz, Langenbeckstr.1, 55131 Mainz, Germany

4. Department of Chemistry, Umeå University, KBC-Building, Linneaus väg 6, S-907 36 Umeå, Sweden

5. Department of Molecular Cell Biology and Immunology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands

6. Amsterdam Institute for Infection and Immunity, Cancer Immunology1105 AZ Amsterdam, the Netherlands

7. Glycosciences Laboratory, Imperial College London, W12 0NN London, U.K.

8. AFFINImeter Scientific & Development Team, Software 4 Science Developments, 15782 Santiago de Compostela, A Coruña, Spain

9. Departamento de Física Aplicada, Facultad de Física, Universidad de Santiago de Compostela, 15705 Santiago de Compostela, Spain

10. Division of Experimental Medicine, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, United States

11. SSPC, the Science Foundation Ireland Research Centre for Pharmaceuticals, University of Galway, University Rd., H91 TK33 Galway, Ireland

Funder

Science Foundation Ireland

Kempestiftelserna

Deutsche Forschungsgemeinschaft

H2020 European Research Council

Irish Research Council for Science, Engineering and Technology

European Molecular Biology Organization

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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