Microphysiological systems for ADME-related applications: current status and recommendations for system development and characterization-Reference-Cited by-同舟云学术

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Microphysiological systems for ADME-related applications: current status and recommendations for system development and characterization

Published:2020 Issue:3 Volume:20 Page:446-467
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Fowler Stephen¹²³⁴^ORCID,Chen Wen Li Kelly⁵⁶⁷,Duignan David B.⁸⁹¹⁰¹¹⁷,Gupta Anshul⁵⁶⁷,Hariparsad Niresh¹²¹³¹⁴⁷,Kenny Jane R.¹⁵¹⁶¹⁷⁷,Lai W. George¹⁵¹⁸¹⁹⁷,Liras Jennifer²⁰²¹⁶⁷^ORCID,Phillips Jonathan A.²²²³¹⁴⁷^ORCID,Gan Jinping²⁴²⁵²⁶⁷^ORCID

Affiliation:

1. Pharma Research and Early Development

2. F.Hoffmann-La Roche Ltd

3. Basel

4. Switzerland

5. Amgen Research

6. Cambridge

7. USA

8. Department of Drug Metabolism

9. Pharmacokinetics & Bioanalysis

10. AbbVie Bioresearch Center

11. Worcester

12. Department of Drug Metabolism and Pharmacokinetics

13. Vertex Pharmaceuticals

14. Boston

15. DMPK

16. Genentech

17. South San Francisco 94080

18. Schrödinger Inc.

19. New York

20. Medicine Design

21. Pfizer Inc

22. Preclinical Safety Assessment

23. Vertex

24. Pharmaceutical Candidate Optimization

25. Bristol-Myers Squibb R&D

26. Princeton

Abstract

Potential applications of MPS in the ADME discipline.

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/LC/C9LC00857H

Reference183 articles.

1. Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

2. Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: a biopharmaceutical perspective

3. A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes

4. Microscale culture of human liver cells for drug development

5. A Novel Relay Method for Determining Low-Clearance Values

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