High throughput methods to measure the propensity of compounds to form intramolecular hydrogen bonding-Reference-Cited by-同舟云学术

High throughput methods to measure the propensity of compounds to form intramolecular hydrogen bonding

Published:2017 Issue:6 Volume:8 Page:1143-1151
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Caron Giulia¹²³⁴^ORCID,Vallaro Maura¹²³⁴,Ermondi Giuseppe¹²³⁴

Affiliation:

1. Molecular Biotechnology and Health Sciences Dept.

2. University of Torino

3. 10135 Torino

4. Italy

Abstract

Implementation of IMHB considerations in drug discovery needs robust and validated descriptors to experimentally verify the propensity of compounds to exhibit IMHBs.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C7MD00101K

Reference58 articles.

1. Conformational Flexibility, Internal Hydrogen Bonding, and Passive Membrane Permeability: Successful in Silico Prediction of the Relative Permeabilities of Cyclic Peptides

2. Intramolecular Hydrogen Bonding in Medicinal Chemistry

3. Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space

4. How hydrogen bonds impact P-glycoprotein transport and permeability

5. Why we need to implement intramolecular hydrogen-bonding considerations in drug discovery

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