Prediction of Chameleonic Efficiency-Reference-Cited by-同舟云学术

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Prediction of Chameleonic Efficiency

Published:2021-08-04 Issue:17 Volume:16 Page:2669-2685
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

David Laurent¹,Wenlock Mark²,Barton Patrick³⁴,Ritzén Andreas⁵⁶^ORCID

Affiliation:

1. Computational Chemistry H. Lundbeck A/S Ottiliavej 9 2300 Valby, Copenhagen Denmark

2. Physical Chemistry Cyprotex Discovery Limited Alderley Park Nether Alderley, Cheshire SK10 4TG UK

3. Evotec (UK) Ltd. 114 Innovation Drive, Milton Park Abingdon, Oxfordshire OX14 4RZ UK

4. DMPK UCB Celltech Branch of UCB Pharma S.A. 208 Bath Road Slough, Berkshire SL1 3WE UK

5. Drug Design LEO Pharma A/S Industriparken 55 2550 Ballerup Denmark

6. Monte Rosa Therapeutics AG Aeschenvorstadt 36 CH 4057 Basel Switzerland

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202100306

Reference33 articles.

1. Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates

2. Quantifying the chameleonic properties of macrocycles and other high-molecular-weight drugs

3. High Throughput Method for the Indirect Detection of Intramolecular Hydrogen Bonding

4. EPSA: A Novel Supercritical Fluid Chromatography Technique Enabling the Design of Permeable Cyclic Peptides

5. Partitioning of Solutes in Different Solvent Systems: The Contribution of Hydrogen-Bonding Capacity and Polarity

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3. Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB₁R);Journal of Medicinal Chemistry;2024-07-11

4. Beyond Rule of Five and PROTACs in Modern Drug Discovery: Polarity Reducers, Chameleonicity, and the Evolving Physicochemical Landscape;Journal of Medicinal Chemistry;2024-03-18

5. Oral Absorption of Middle-to-Large Molecules and Its Improvement, with a Focus on New Modality Drugs;Pharmaceutics;2023-12-28

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