Beyond Rule of Five and PROTACs in Modern Drug Discovery: Polarity Reducers, Chameleonicity, and the Evolving Physicochemical Landscape
Author:
Affiliation:
1. Research and Development, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States
Publisher
American Chemical Society (ACS)
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02332
Reference78 articles.
1. Global Analysis of Models for Predicting Human Absorption: QSAR, In Vitro, and Preclinical Models
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4. Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates
5. Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation
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