MeOx-TMS derivatization for GC-MS metabolic profiling of urine and application in the discrimination between normal C57BL/6J and type 2 diabetic KK-Ay mice-Reference-Cited by-同舟云学术

MeOx-TMS derivatization for GC-MS metabolic profiling of urine and application in the discrimination between normal C57BL/6J and type 2 diabetic KK-Ay mice

Published:2014 Issue:12 Volume:6 Page:4380-4387
ISSN:1759-9660
Container-title:Anal. Methods
language:en
Short-container-title:Anal. Methods

Author:

Yi Lunzhao¹²³⁴⁵,Shi Shuting⁴⁵⁶,Yi Zhibiao⁷⁸⁹,He Ruihua⁴⁵⁶,Lu Hongmei⁴⁵⁶,Liang Yizeng⁴⁵⁶

Affiliation:

1. Yunnan Food Safety Research Institute

2. Kunming University of Science and Technology

3. Kunming, P.R. China

4. College of Chemistry and Chemical Engineering

5. Central South University

6. Changsha, P.R. China

7. Dongguan Mathematical and Engineering Academy of Chinese Medicine

8. GuangZhou University of Chinese Medicine

9. Dongguan, P.R. China

Abstract

GC-MS-based protocol using methoximation followed by silylation with BSTFA + 1%TMCS for the analysis of urine metabolites.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/AY/C3AY41522H

Reference22 articles.

1. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

2. Serum metabolite signature predicts the acute onset of diabetes in spontaneously diabetic congenic BB rats

3. Diagnosis of liver cancer using HPLC-based metabonomics avoiding false-positive result from hepatitis and hepatocirrhosis diseases

4. The Mechanism of Galactosamine Toxicity Revisited; A Metabonomic Study

5. GC/MS-based metabolomic approach to validate the role of urinary sarcosine and target biomarkers for human prostate cancer by microwave-assisted derivatization

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