Synthesis and inhibitory activity against MurA and MurZ enzymes of 4H-pyrano[2,3-d]pyrimidine–1H-1,2,3-triazole hybrid compounds having piperidine and morpholine rings-Reference-Cited by-同舟云学术

Synthesis and inhibitory activity against MurA and MurZ enzymes of 4H-pyrano[2,3-d]pyrimidine–1H-1,2,3-triazole hybrid compounds having piperidine and morpholine rings

Published:2023 Issue:25 Volume:47 Page:11800-11821
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Nguyen Dinh Thanh¹^ORCID,Do Son Hai¹²,Vu Ngoc Toan¹³,Hoang Thi Kim Van¹⁴,Nguyen Thi Kim Giang¹²,Nguyen Minh Tri¹³,Hoang Huu Anh¹,Duong Ngoc Toan¹⁵

Affiliation:

1. Faculty of Chemistry, University of Science (Vietnam National University, Hanoi), 19 Le Thanh Tong, Ha Noi, Vietnam

2. Institute of Science and Technology, Ministry of Public Security of Vietnam, 47 Pham Van Dong, Cau Giay, Ha Noi, Vietnam

3. Faculty of Chemical Technology, Viet Tri University of Industry, Tien Kien, Lam Thao, Phu Tho, Vietnam

4. Institute of New Technology, Military Institute of Science and Technology (Ministry of Military), Cau Giay, Ha Noi, Vietnam

5. Faculty of Chemistry, Thai Nguyen University of Education, 20 Luong Ngoc Quyen, Thai Nguyen, Vietnam

Abstract

A series of 1H-1,2,3-triazoles 12a–g and 13a–g having 4H-pyrano[2,3-d]pyrimidine and d-glucose rings was synthesized by click chemistry and their inhibitory activity against UDP-N-acetylglucosamine enolpyruvyl transferases (MurA & MurZ) was examined.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D3NJ01718D

Reference53 articles.

1. The role of adjuvants in overcoming antibacterial resistance due to enzymatic drug modification

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4. Inhibition of MurA Enzyme from Escherichia coli and Staphylococcus aureus by Diterpenes from Lepechinia meyenii and Their Synthetic Analogs

5. Advances in UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA) Covalent Inhibition

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