The role of adjuvants in overcoming antibacterial resistance due to enzymatic drug modification-Reference-Cited by-同舟云学术

The role of adjuvants in overcoming antibacterial resistance due to enzymatic drug modification

Published:2022 Issue:11 Volume:13 Page:1276-1299
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

El-Khoury Christy¹,Mansour Elissar¹^ORCID,Yuliandra Yori¹^ORCID,Lai Felcia¹,Hawkins Bryson A.¹^ORCID,Du Jonathan J.²,Sundberg Eric J.²,Sluis-Cremer Nicolas³,Hibbs David E.¹^ORCID,Groundwater Paul W.¹^ORCID

Affiliation:

1. Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia

2. Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, 30322, USA

3. Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA

Abstract

Enzymatic drug deactivation is an important contributor to bacterial resistance. Adjuvants which inhibit the β-lactamases help maintain the efficacy of the β-lactams, demonstrating the potential for this strategy for other antibacterial classes.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D2MD00263A

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