Mechanistic insights into dopaminergic and serotonergic neurotransmission – concerted interactions with helices 5 and 6 drive the functional outcome-Reference-Cited by-同舟云学术

Mechanistic insights into dopaminergic and serotonergic neurotransmission – concerted interactions with helices 5 and 6 drive the functional outcome

Published:2021 Issue:33 Volume:12 Page:10990-11003
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Stepniewski Tomasz Maciej¹²^ORCID,Mancini Arturo³,Ågren Richard⁴,Torrens-Fontanals Mariona¹^ORCID,Semache Meriem³,Bouvier Michel⁵⁶^ORCID,Sahlholm Kristoffer⁴⁷^ORCID,Breton Billy³⁶,Selent Jana¹^ORCID

Affiliation:

1. Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM) – Pompeu Fabra University (UPF), Dr Aiguader 88, Barcelona, E-08003, Spain

2. InterAx Biotech AG, PARK InnovAARE, 5234 Villigen, Switzerland

3. Domain Therapeutics NA Inc, 7171 Frederick-Banting, Saint-Laurent (QC) H4S 1Z9, Canada

4. Department of Neuroscience, Karolinska Institute, Stockholm, Sweden

5. Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, QC H3C 3J7, Canada

6. Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Québec, H3T 1J4, Canada

7. Department of Integrative Medical Biology, Wallenberg Centre for Molecular Medicine, Umeå University, 90187, Umeå, Sweden

Abstract

Neurotransmitter contacts within the receptor binding site differentially contribute to the overall functional response: transmembrane helix (TM) 5 contacts promote G protein coupling whereas concerted TM5–TM6 contacts enhance β-arrestin recruitment.

Funder

Ministerio de Ciencia e Innovación

Instituto de Salud Carlos III

Ministerio de Economía, Industria y Competitividad, Gobierno de España

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC00749A

Reference49 articles.

1. L. J.Elias and D. M.Saucier , Neuropsychology: clinical and experimental foundations , Pearson/Allyn & Bacon , 2006