Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery
Author:
Publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)
Subject
Pharmacology,Molecular Medicine
Reference554 articles.
1. AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration
2. Allosteric inhibitors of Bcr-abl–dependent cell proliferation
3. Desensitization, internalization, and signaling functions of -arrestins demonstrated by RNA interference
4. Differential Kinetic and Spatial Patterns of β-Arrestin and G Protein-mediated ERK Activation by the Angiotensin II Receptor
5. Gq/11and Gi/oactivation profiles in CHO cells expressing human muscarinic acetylcholine receptors: dependence on agonist as well as receptor-subtype
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