Tuning protein folding in lysosomal storage diseases: the chemistry behind pharmacological chaperones
Author:
Affiliation:
1. REQUIMTE/LAQV
2. Laboratório de Farmacognosia
3. Departamento de Química
4. Faculdade de Farmácia
5. Universidade do Porto
Abstract
We review pharmacological chaperones used in lysosomal storage diseases, emphasizing medicinal chemistry approaches and mechanisms of action.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/SC/C7SC04712F
Reference84 articles.
1. Azasugar inhibitors as pharmacological chaperones for Krabbe disease
2. Docking study and biological evaluation of pyrrolidine-based iminosugars as pharmacological chaperones for Gaucher disease
3. The therapeutic potential of chemical chaperones in protein folding diseases
4. 4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor
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