4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor-Reference-Cited by-同舟云学术

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4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor

Published:2013-11 Issue:21 Volume:23 Page:6015-6018
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Mimori Seisuke,Ohtaka Hiroyasu,Koshikawa Yukari,Kawada Koichi,Kaneko Masayuki,Okuma Yasunobu,Nomura Yasuyuki,Murakami Yasuoki,Hamana Hiroshi

Funder

Sasakawa Scientific Research Grant from The Japan Science Society

Grants-in-Aid for Scientific Research

Ministry of Education, Culture, Sports, Science and Technology, Japan

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference22 articles.

1. Oral sodium phenylbutyrate therapy in homozygous beta thalassemia: a clinical trial

2. A Pilot Clinical Trial of Oral Sodium 4-Phenylbutyrate (Buphenyl) in Δ F508-Homozygous Cystic Fibrosis Patients

3. Evidence of CFTR Function in Cystic Fibrosis after Systemic Administration of 4-Phenylbutyrate

4. Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

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1. Neurodegenerative diseases associated with the disruption of proteostasis and their therapeutic strategies using chemical chaperones;The Journal of Biochemistry;2024-07-02

2. Updates on Aβ Processing by Hsp90, BRICHOS, and Newly Reported Distinctive Chaperones;Biomolecules;2023-12-22

3. 4-Phenylbutyric acid attenuates amyloid-β proteotoxicity through activation of HSF-1 in an Alzheimer's disease model of the nematode Caenorhabditis elegans;Biochemical and Biophysical Research Communications;2023-09

4. Chemical chaperon 4-phenylbutric acid improves cardiac function following isoproterenol-induced myocardial infarction in rats;IRAN J BASIC MED SCI;2023

5. Multidimensional analysis and therapeutic development using patient iPSC–derived disease models of Wolfram syndrome;JCI Insight;2022-09-22

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