Azasugar inhibitors as pharmacological chaperones for Krabbe disease-Reference-Cited by-同舟云学术

Azasugar inhibitors as pharmacological chaperones for Krabbe disease

Published:2015 Issue:5 Volume:6 Page:3075-3086
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Hill Chris H.¹²³⁴⁵,Viuff Agnete H.⁶⁷⁸,Spratley Samantha J.¹²³⁴⁵,Salamone Stéphane⁶⁷⁸,Christensen Stig H.⁶⁷⁸,Read Randy J.¹²³⁴⁵,Moriarty Nigel W.⁹¹⁰¹¹¹²,Jensen Henrik H.⁶⁷⁸,Deane Janet E.¹²³⁴⁵

Affiliation:

1. Department of Haematology

2. Cambridge Institute for Medical Research

3. University of Cambridge

4. Cambridge CB2 0XY

5. UK

6. Department of Chemistry

7. Aarhus University

8. Denmark

9. Physical Biosciences Division

10. Lawrence Berkeley National Laboratory

11. Berkeley

12. USA

Abstract

Modified azasugar molecules have been synthesized and characterized as excellent pharmacological chaperone candidates to treat the neurodegenerative disorder Krabbe disease.

Funder

Wellcome Trust

Royal Society

Lundbeckfonden

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/SC/C5SC00754B

Reference85 articles.

1. Krabbe's Disease