Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery-Reference-Cited by-同舟云学术

Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery

Published:2014 Issue:5 Volume:5 Page:655-658
ISSN:2040-2503
Container-title:Med. Chem. Commun.
language:en
Short-container-title:Med. Chem. Commun.

Author:

Patel Gautam¹²,Roncal Norma E.³⁴⁵,Lee Patricia J.³⁴⁵,Leed Susan E.³⁴⁵,Erath Jessey⁶⁷⁸,Rodriguez Ana⁷⁹¹⁰⁸⁶,Sciotti Richard J.³⁴⁵,Pollastri Michael P.¹²

Affiliation:

1. Northeastern University Department of Chemistry & Chemical Biology

2. Boston, USA

3. Experimental Therapeutics

4. Walter Reed Army Institute for Research

5. Silver Spring, USA

6. Anti-Infectives Screening Core

7. New York University School of Medicine

8. New York, USA

9. Department of Microbiology

10. Division of Parasitology

Abstract

Hesperadin, an established human Aurora B inhibitor, was tested against cultures of Trypanosoma brucei, Leishmania major, and Plasmodium falciparum, and was identified to be a potent proliferation inhibitor.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MD/C4MD00045E

Reference15 articles.

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3. The Susceptibility of Trypanosomatid Pathogens to PI3/mTOR Kinase Inhibitors Affords a New Opportunity for Drug Repurposing

4. The human Aurora kinase inhibitor danusertib is a lead compound for anti-trypanosomal drug discovery via target repurposing

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