Metabolism of secoisolariciresinol-diglycoside the dietary precursor to the intestinally derived lignan enterolactone in humans

Author:

Setchell Kenneth D. R.12345,Brown Nadine M.1234,Zimmer-Nechemias Linda1234,Wolfe Brian1234,Jha Pinky1234,Heubi James E.67845

Affiliation:

1. Division of Pathology

2. Clinical Mass Spectrometry

3. Cincinnati Children's Hospital Medical Center

4. Cincinnati, USA

5. University of Cincinnati College of Medicine

6. Division of Gastroenterology and Nutrition

7. Department of Pediatrics

8. Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine

Abstract

Secoisolariciresinol-diglycoside (SDG), a natural dietary lignan of flaxseeds now available in dietary supplements, is converted by intestinal bacteria to the mammalian lignans enterodiol and enterolactone.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Reference76 articles.

1. K. D. R. Setchell and H.Adlercreutz , in Role of the Gut Flora in Toxicity and Cancer , ed. I. R. Rowland , Academic Press , London, UK , 1988 , pp. 315–334

2. Mammalian lignan production from various foods

3. Chemical Studies of Phytoestrogens and Related Compounds in Dietary Supplements: Flax and Chaparral

4. Variability in anticancer lignan levels in flaxseed

5. N. D. Westcott , A. D.Muir and S. F.Northrup , Analysis of flax lignans after enzymatic and chemical extraction , Fargo , North Dakota , 1998

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