Straightforward access to 4-membered sulfurated heterocycles: introducing a strategy for the single and double functionalization of thietane 1-oxide

Author:

Carroccia Laura123,Degennaro Leonardo123,Romanazzi Giuseppe453,Cuocci Corrado67,Pisano Luisa8910,Luisi Renzo123

Affiliation:

1. Department of Pharmacy – Drug Sciences

2. University of Bari “A. Moro”

3. Bari 70125 – I, Italy

4. DICATECh

5. Polytechnic of Bari

6. Istituto di Cristallografia (IC-CNR)

7. 70125 Bari – I, Italy

8. Department of Chemistry and Pharmacy

9. University of Sassari

10. 07100 Sassari – I, Italy

Abstract

A strategy for the stereoselective functionalization of thietane 1-oxide has been developed by using the corresponding organometallic intermediates that reacted with electrophiles leaving intact the 4-membered ring.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference37 articles.

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2. Four-membered Heterocycles together with all Fused Systems containing a Four-membered Heterocyclic Ring in Comprehensive Heterocyclic Chemistry III , ed. A. R. Katritzky , C. A. Ramsden , E. F. V. Scriven and R. J. K. Taylor , Elsevier Ltd , 2008 , vol. 2 , pp. 1–989

3. Using Fragment-Based Technologies to Target Protein-Protein Interactions

4. Route to three-dimensional fragments using diversity-oriented synthesis

5. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

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