Development of a Continuous Flow Synthesis of 2-Substituted Azetines and 3-Substituted Azetidines by Using a Common Synthetic Precursor-Reference-Cited by-同舟云学术

Development of a Continuous Flow Synthesis of 2-Substituted Azetines and 3-Substituted Azetidines by Using a Common Synthetic Precursor

Published:2021-07-22 Issue:20 Volume:86 Page:13943-13954
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Colella Marco¹,Musci Pantaleo¹,Cannillo Debora¹,Spennacchio Mauro¹,Aramini Andrea²,Degennaro Leonardo¹^ORCID,Luisi Renzo¹^ORCID

Affiliation:

1. FLAME-Lab, Flow Chemistry and Microreactor Technology Laboratory, Department of Pharmacy − Drug Sciences, University of Bari “A. Moro”, Via E. Orabona 4, 70125 Bari, Italy

2. Department of Discovery, Dompé Farmaceutici S.p.A., Via Campo di Pile, L’Aquila 67100, Italy

Funder

Domp?? Farmaceutici

Ministero dell'Istruzione, dell'Universit?? e della Ricerca

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.1c01297

Reference75 articles.

1. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

2. Total Syntheses of Phytosiderophores, 3-Epi-Hydroxymugineic Acid, Distichonic Acid A, and 2′-Hydroxynicotianamine

3. An Efficient Stereoselective Synthesis of Penaresidin A from (E)-2-Protected Amino-3,4-unsaturated Sulfoxide

4. Mitigating Heterocycle Metabolism in Drug Discovery

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