DNA-friendly Cu(ii)/TEMPO-catalyzed 5-hydroxymethylcytosine-specific oxidation-Reference-Cited by-同舟云学术

DNA-friendly Cu(ii)/TEMPO-catalyzed 5-hydroxymethylcytosine-specific oxidation

Published:2017 Issue:42 Volume:53 Page:5756-5759
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Matsushita Taku¹²³⁴⁵,Moriyama Yuya¹²³⁴⁵,Nagae Genta⁶⁷³⁸⁵,Aburatani Hiroyuki⁶⁷³⁸⁵,Okamoto Akimitsu¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry and Biotechnology

2. Graduate School of Engineering

3. The University of Tokyo

4. Bunkyo-ku

5. Japan

6. Genome Science Division

7. Research Center for Advanced Science and Technology

8. Meguro-ku

Abstract

An allyl alcohol-selective oxidant Cu(ii)/TEMPO complex makes it possible to specifically detect 5-hydroxymethylcytosine in the human brain genome using a DNA sequence analyzer after a very easy pretreatment.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C7CC02814H

Reference30 articles.

1. Oxidative DNA damage: mechanisms, mutation, and disease

2. Purification and characterization of Escherichia coli formamidopyrimidine-DNA glycosylase that excises damaged 7-methylguanine from deoxyribonucleic acid

3. 5,6-Saturated thymine lesions in DNA: production by ultraviolet light or hydrogen peroxide

4. Dihydrothymine from UV-irradiated DNA.

5. Active DNA demethylation: many roads lead to Rome

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