Cascade reaction of isatins with nitro-substituted enamines: highly selective synthesis of functionalized (Z)-3-(1-(arylamino)-2-oxoarylidene)indolin-2-ones

Author:

Zhang Cong-Hai12345,Huang Rong12345,Qing Xia12345,Lin Jun12345ORCID,Yan Sheng-Jiao12345ORCID

Affiliation:

1. Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University)

2. Ministry of Education and Yunnan Province

3. School of Chemical Science and Technology

4. Yunnan University

5. Kunming

Abstract

A novel protocol for the construction of functionalized (Z)-3-(1(-arylamino)-2-oxoarylidene)indolin-2-ones (AOIDOs) from isatins 1 with nitro-substituted enamines 2via an unprecedented cascade reaction catalyzed by sulfamic acid is developed.

Funder

Applied Basic Research Foundation of Yunnan Province

Ministry of Education of the People's Republic of China

Yunnan Provincial Department of Education

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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