Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria-Reference-Cited by-同舟云学术

Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria

Published:2010-06-22 Issue:14 Volume:53 Page:5155-5164
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yeung Bryan K. S.¹²³⁴⁵,Zou Bin¹²³⁴⁵,Rottmann Matthias¹²³⁴⁵,Lakshminarayana Suresh B.¹²³⁴⁵,Ang Shi Hua¹²³⁴⁵,Leong Seh Yong¹²³⁴⁵,Tan Jocelyn¹²³⁴⁵,Wong Josephine¹²³⁴⁵,Keller-Maerki Sonja¹²³⁴⁵,Fischli Christoph¹²³⁴⁵,Goh Anne¹²³⁴⁵,Schmitt Esther K.¹²³⁴⁵,Krastel Philipp¹²³⁴⁵,Francotte Eric¹²³⁴⁵,Kuhen Kelli¹²³⁴⁵,Plouffe David¹²³⁴⁵,Henson Kerstin¹²³⁴⁵,Wagner Trixie¹²³⁴⁵,Winzeler Elizabeth A.¹²³⁴⁵,Petersen Frank¹²³⁴⁵,Brun Reto¹²³⁴⁵,Dartois Veronique¹²³⁴⁵,Diagana Thierry T.¹²³⁴⁵,Keller Thomas H.¹²³⁴⁵

Affiliation:

1. Novartis Institute for Tropical Diseases, 10 Biopolis Road, no. 05-01 Chromos, Singapore 138670

2. Swiss Tropical and Public Health Institute, Parasite Chemotherapy, Socinstrasse 57, Basel, Switzerland CH-4002

3. Natural Products Unit, Novartis Pharma AG, Basel, Switzerland CH-4002

4. Novartis Institute for Biomedical Research, Basel, Switzerland CH-4056

5. Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Drive, San Diego, California 92121

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/jm100410f

Reference21 articles.

1. a World Health Organization World Malaria Report 2009; World Health Organization: Geneva, 2009; World Health Organization website: http://www.who.int/malaria/publications/atoz/9789241563901/en/index.html, accessed 15 December 2009.

2. WHO estimates of the causes of death in children

3. Qinghaosu (Artemisinin): The Price of Success

4. Artemisinin Resistance inPlasmodium falciparumMalaria

5. Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6

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