Stereochemical insights into β-amino-<i>N</i>-acylhydrazones and their impact on DPP-4 inhibition-Reference-Cited by-同舟云学术

Stereochemical insights into β-amino-N-acylhydrazones and their impact on DPP-4 inhibition

Published:2024 Issue:10 Volume:14 Page:6617-6626
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Reina Eduardo¹,Franco Lucas Silva¹²^ORCID,Carneiro Teiliane Rodrigues¹,Barreiro Eliezer J.¹²^ORCID,Lima Lidia Moreira¹²^ORCID

Affiliation:

1. Instituto Nacional de Ciência e Tecnologia de Fármacos e Medicamentos (INCT-INOFAR), Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio®), Universidade Federal do Rio de Janeiro (UFRJ), CCS, Cidade Universitária, Rio de Janeiro-RJ, Brazil

2. Pós-graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro-RJ, Brazil

Abstract

DPP-4 is a pharmacological target that remains of considerable ongoing interest. Here, we describe original DPP4 inhibitors bearing a new β-amino-N-acylhydrazone framework and the impact of stereochemistry on the inhibition profile.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Instituto Nacional de Ciência e Tecnologia de Fármacos e Medicamentos

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA00450G

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