Design, synthesis, molecular simulation, and biological activities of novel quinazolinone-pyrimidine hybrid derivatives as dipeptidyl peptidase-4 inhibitors and anticancer agents-Reference-Cited by-同舟云学术

Design, synthesis, molecular simulation, and biological activities of novel quinazolinone-pyrimidine hybrid derivatives as dipeptidyl peptidase-4 inhibitors and anticancer agents

Published:2020 Issue:45 Volume:44 Page:19515-19531
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Emami Leila¹²³⁴⁵,Faghih Zahra⁶⁷³⁴⁵,Sakhteman Amirhossein¹²³⁴⁵,Rezaei Zahra¹²³⁴⁵,Faghih Zeinab⁸³⁴⁵,Salehi Farnaz¹²³⁴⁵,Khabnadideh Soghra¹²³⁴⁵^ORCID

Affiliation:

1. Department of Medicinal Chemistry

2. School of Pharmacy

3. Shiraz University of Medical Sciences

4. Shiraz

5. Iran

6. Shiraz Institute for Cancer Research

7. Medical School

8. Pharmaceutical Sciences Research Center

Abstract

Twelve novel quinazolinone–pyrimidine hybrids were synthesized, of which some of them showed dual functions as DPP-4 inhibitors and anti-cancer agents.

Funder

Shiraz University of Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NJ/D0NJ03774E

Reference54 articles.

1. The Protease Complex Consisting of Dipeptidyl Peptidase IV and Seprase Plays a Role in the Migration and Invasion of Human Endothelial Cells in Collagenous Matrices

2. Interaction of plasminogen with dipeptidyl peptidase IV initiates a signal transduction mechanism which regulates expression of matrix metalloproteinase-9 by prostate cancer cells

3. CD26 Expression on T-Anaplastic Large Cell Lymphoma (ALCL) Line Karpas 299 is associated with increased expression of Versican and MT1-MMP and enhanced adhesion

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