Ureidopeptide GLP-1 analogues with prolonged activity in vivo via signal bias and altered receptor trafficking-Reference-Cited by-同舟云学术

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Ureidopeptide GLP-1 analogues with prolonged activity in vivo via signal bias and altered receptor trafficking

Published:2019 Issue:42 Volume:10 Page:9872-9879
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Fremaux Juliette¹²³,Venin Claire¹²³,Mauran Laura¹²³,Zimmer Robert¹²³,Koensgen Florian⁴⁵⁶⁷³,Rognan Didier⁴⁵⁶⁷³^ORCID,Bitsi Stavroula⁸⁹¹⁰¹¹,Lucey Maria A.¹²⁹¹⁰¹¹,Jones Ben¹²⁹¹⁰¹¹,Tomas Alejandra⁸⁹¹⁰¹¹,Guichard Gilles¹³¹⁴¹⁵¹⁶¹⁷^ORCID,Goudreau Sébastien R.¹²³^ORCID

Affiliation:

1. UREkA – ImmuPharma Group

2. 33607 Pessac

3. France

4. Laboratoire d'Innovation Thérapeutique

5. UMR7200 CNRS-Université de Strasbourg

6. 74 route du Rhin

7. 67400 Illkirch

8. Section of Cell Biology and Functional Genomics

9. Imperial College London

10. London W12 0NN

11. UK

12. Section of Investigative Medicine

13. Univ. Bordeaux

14. CNRS

15. CBMN

16. UMR 5248

17. Institut Européen de Chimie et Biologie

Abstract

This study demonstrates the efficacy of single α-amino acids substitution with ureido residues to design long lasting peptides.

Funder

Agence Nationale de la Recherche

Medical Research Council

Université de Bordeaux

Centre National de la Recherche Scientifique

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC02079A

Reference34 articles.

1. Peptide chemistry toolbox – Transforming natural peptides into peptide therapeutics

2. New Modalities for Challenging Targets in Drug Discovery

3. Azapeptide Synthesis Methods for Expanding Side-Chain Diversity for Biomedical Applications

4. Aza-Glycine Induces Collagen Hyperstability

5. L. M. Johnson and S. H.Gellman , in Methods in Enzymology , Elsevier , 2013 , vol. 523 , pp. 407–429

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