Cyclisation strategies for stabilising peptides with irregular conformations
Author:
Affiliation:
1. School of Chemistry, Eastern Ave
2. The University of Sydney
3. Australia
4. Bioinformatics Institute
5. Agency for Science, Technology and Research (A*STAR)
6. Singapore 138671
7. Singapore
Abstract
There are remarkably few examples of designing cyclic constraints for peptides which adopt an irregular conformation in their bioactive state. We discuss the design strategies, opportunities and challenges for this underexplored class of inhibitors.
Funder
Australian Research Council
Westpac Scholars Trust
National Health and Medical Research Council
Agency for Science, Technology and Research
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00098E
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