Addressing Challenges of Macrocyclic Conformational Sampling in Polar and Apolar Solvents: Lessons for Chameleonicity
Author:
Affiliation:
1. Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, A-6020 Innsbruck, Austria
2. Department of Chemistry and Applied Biosciences, ETH Zürich, 8093 Zürich, Switzerland
Funder
Austrian Science Fund
H2020 Marie Sklodowska-Curie Actions
Publisher
American Chemical Society (ACS)
Subject
Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.3c01123
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1. Macrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug Discovery
2. How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets
3. Cyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein-Protein Interactions
4. Trends in peptide drug discovery
5. The exploration of macrocycles for drug discovery — an underexploited structural class
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