Development of an efficient route toward meiogynin A-inspired dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins-Reference-Cited by-同舟云学术

Development of an efficient route toward meiogynin A-inspired dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins

Published:2015 Issue:19 Volume:13 Page:5520-5531
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Desrat Sandy¹²³⁴⁵,Remeur Camille¹²³⁴⁵,Roussi Fanny¹²³⁴⁵

Affiliation:

1. Centre de Recherche de Gif

2. Institut de Chimie des Substances Naturelles (ICSN)

3. CNRS UPR 2301

4. Université Paris Sud Labex CEBA

5. 91 198 Gif-sur-Yvette Cedex

Abstract

The synthesis, on a large scale, with very good yield and er via an efficient strategy, of a chiral 4-substituted 2-cyclohexenone intermediate, was a milestone in the synthesis of seven analogues of meiogynin A, a natural sesquiterpenoid dimer.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00354G

Reference47 articles.

1. A Dimeric Sesquiterpenoid from a Malaysian Meiogyne as a New Inhibitor of Bcl-xL/BakBH3 Domain Peptide Interaction

2. Pro-apoptotic meiogynin A derivatives that target Bcl-xL and Mcl-1

3. Many players in BCL-2 family affairs

4. Unique Biology of Mcl-1: Therapeutic Opportunities in Cancer

5. Bcl-2–family proteins and hematologic malignancies: history and future prospects

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