Synthesis and biological evaluation of FJ-809, a compound originally described as MIM1 and an inhibitor of the anti-apoptotic protein Mcl-1-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of FJ-809, a compound originally described as MIM1 and an inhibitor of the anti-apoptotic protein Mcl-1

Published:2022 Issue:19 Volume:46 Page:9119-9127
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Justaud Frédéric¹,Paysant Hippolyte²³,Weiswald Louis Bastien²³,Jebahi Abdelghani²³,Jouanne Marie⁴,Elie Nicolas⁵^ORCID,Voisin-Chiret Anne Sophie⁴,Roisnel Thierry¹^ORCID,Orione Clément⁶,Levoin Nicolas⁷,Poulain Laurent²³,Grée René¹^ORCID

Affiliation:

1. Univ Rennes, CNRS, ISCR (Institut des Sciences Chimiques de Rennes), UMR 6226, F-35000, Rennes, France

2. Normandie Université, UNICAEN, Inserm U1086 ANTICIPE «Unité de Recherche Interdisciplinaire pour la Prévention et le Traitement des Cancers», France

3. UNICANCER, Centre de Lutte Contre le Cancer F. Baclesse, 3 avenue du Général Harris, 14076, Caen, France

4. Normandie Université, UNICAEN, EA 4258 CERMN (Centre d'Etudes et de Recherche sur le Médicament de Normandie) - FR CNRS INC3M, Caen, France

5. Normandie Université, UNICAEN, Structure Fédérative 4206 ICORE, Centre de Microscopie appliqué à la Biologie (CMABIO3), France

6. Univ Rennes, CRMPO (Centre Régional de Mesures Pysiques de l’Ouest), Avenue du Général Leclerc, 35042 Rennes Cedex, France

7. Bioprojet-Biotech, 4 rue du Chesnay Beauregard, BP 96205, 35762, Saint Grégoire, France

Abstract

The development of inhibitors of anti-apoptotic proteins, such as Mcl-1, is currently a very active area in the field of cancer research.

Funder

Université de Rennes 1

Conseil Régional de Haute Normandie

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D1NJ05987D

Reference41 articles.

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