A covalent G-site inhibitor for glutathione S-transferase Pi (GSTP1-1)-Reference-Cited by-同舟云学术

A covalent G-site inhibitor for glutathione S-transferase Pi (GSTP1-1)

Published:2017 Issue:81 Volume:53 Page:11138-11141
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Shishido Yuko¹²³⁴⁵,Tomoike Fumiaki¹²³⁴⁵^ORCID,Kimura Yasuaki¹²³⁴⁵^ORCID,Kuwata Keiko⁶³⁴⁵,Yano Takato⁷⁸⁹⁵,Fukui Kenji⁷⁸⁹⁵,Fujikawa Haruka¹²³⁴⁵,Sekido Yoshitaka¹⁰¹¹⁴⁵,Murakami-Tonami Yuko¹⁰¹¹⁴⁵,Kameda Tomoshi¹²¹³¹⁴⁵,Shuto Satoshi¹⁵¹⁶¹⁷⁵,Abe Hiroshi¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Graduate School of Science

3. Nagoya University

4. Nagoya

5. Japan

6. Institute of Transformative Bio-Molecules (WPI-ITbM)

7. Department of Biochemistry

8. Osaka Medical College

9. Takatsuki

10. Division of Molecular Oncology

11. Aichi Cancer Center Research Institute

12. Artificial Intelligence Research Center

13. National Institute of Advanced Industrial Science and Technology

14. Tokyo

15. Faculty of Pharmaceutical Science

16. Hokkaido University

17. Sapporo

Abstract

We herein report the first covalent G-site-binding inhibitor for GST, GS-ESF (1), which irreversibly inhibited the GSTP_1-1 function.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C7CC05829B

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5. Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells

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