Scaffold-hopping as a strategy to address metabolic liabilities of aromatic compounds-Reference-Cited by-同舟云学术

Scaffold-hopping as a strategy to address metabolic liabilities of aromatic compounds

Published:2020 Issue:1 Volume:11 Page:18-29
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Lazzara Phillip R.¹²³⁴⁵^ORCID,Moore Terry W.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences

2. College of Pharmacy

3. University of Illinois at Chicago

4. Chicago

5. USA

Abstract

Mitigating oxidative drug metabolism is an important component of lead optimization. This review focuses on scaffold-hopping strategies used in the recent medicinal chemistry literature to address metabolic liabilities of aromatic compounds.

Funder

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MD/C9MD00396G

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