Late-stage peptide labeling with near-infrared fluorogenic nitrobenzodiazoles by manganese-catalyzed C

Late-stage peptide labeling with near-infrared fluorogenic nitrobenzodiazoles by manganese-catalyzed C–H activation

Published:2023 Issue:21 Volume:14 Page:5728-5733
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Oyama Tsuyoshi¹,Mendive-Tapia Lorena²^ORCID,Cowell Verity²,Kopp Adelina¹,Vendrell Marc²^ORCID,Ackermann Lutz¹³^ORCID

Affiliation:

1. Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammanstraße 2, 37077, Göttingen, Germany

2. Centre for Inflammation Research, The University of Edinburgh, EH16 4TJ Edinburgh, UK

3. German Center for Cardiovascular Research (DZHK), Potsdamer Straße 58, 10785, Berlin, Germany

Abstract

This manganese-catalyzed late-stage NBD peptide labeling featured excellent site- and diastereo-E-selectivity, enabling large Stokes shifts, fluorogenic NIR emission, and application for real-time imaging of live bacteria under wash free conditions.

Funder

Deutsche Forschungsgemeinschaft

H2020 European Research Council

Horizon 2020 Framework Programme

Wellcome Trust

Deutsches Zentrum für Herz-Kreislaufforschung

Leibniz-Gemeinschaft

University of Edinburgh

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC01868G

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