An evaluation of credentials of a multicomponent reaction for the synthesis of isothioureas through the use of a holistic CHEM21 green metrics toolkit

Author:

Abou-Shehada S.12345,Mampuys P.6789,Maes B. U. W.6789,Clark J. H.12345,Summerton L.12345

Affiliation:

1. Green Chemistry Centre of Excellence

2. University of York

3. Heslington

4. York

5. UK

6. Department of Chemistry

7. University of Antwerp

8. 2020 Antwerp

9. Belgium

Abstract

Multicomponent reactions (MCRs) are considered green and material efficient methods for the synthesis of organic compounds, however very few studies have investigated the metrics of the upstream processes involved to achieve the starting materials used in these reactions.

Funder

Fonds Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Reference39 articles.

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2. J. Andraos , in Green Chemistry Metrics: Measuring and Monitoring Sustainable Processes, ed. A. Lapkin and D. J. C. Constable, Blackwell, 2009

3. D. J. C. Constable , C.Jimenez-Gonzalez and A.Lapkin, in Green Chemistry Metrics: Measuring and Monitoring Sustainable Processes, ed. A. Lapkin and D. J. C. Constable, Blackwell, 2009

4. Towards a holistic approach to metrics for the 21st century pharmaceutical industry

5. In vitro activity of S-(3,4-dichlorobenzyl)isothiourea hydrochloride and novel structurally related compounds against multidrug-resistant bacteria, including Pseudomonas aeruginosa and Burkholderia cepacia complex

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