Preparation of new bicyclo[2.1.1]hexane compact modules: an opening towards novel sp<sup>3</sup>-rich chemical space-Reference-Cited by-同舟云学术

Preparation of new bicyclo[2.1.1]hexane compact modules: an opening towards novel sp³-rich chemical space

Published:2022 Issue:46 Volume:20 Page:9108-9111
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Herter Loïc¹²^ORCID,Koutsopetras Ilias²,Turelli Lorenzo²,Fessard Thomas¹,Salomé Christophe¹^ORCID

Affiliation:

1. SpiroChem AG: Rosental area, WRO-1047-3, Mattenstrasse 22, 4058 Basel, Switzerland

2. Bio-Functional Chemistry (UMR 7199), LabEx Medalis, University of Strasbourg, 74 Route du Rhin, Illkirch, 67400, France

Abstract

Here, we disclose an efficient and modular approach toward new 1,2-disubstituted bicyclo[2.1.1]hexane modules via [2 + 2] cycloaddition. The system can readily be derivatized with numerous transformations, opening the gate to sp3-rich new chemical space.

Funder

H2020 Marie Skłodowska-Curie Actions

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01669A

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