Diterpenoids with a novel 6/5-5 spiro tricyclic skeleton from Orthosiphon wulfenioides and their NLRP3 inflammasome inhibitory activity

Author:

Tu Wen-Chao12,Zhang Xing-Jie1,Zhao Ying-Xin1,Chen Wei-Chi2,Zhang Xing-Yu2,Yang Chang-Lin2,Zeb Muhammad Aurang1,Li Xiao-Li1,Sakah Kaunda-Joseph1,Zhang Rui-Han1ORCID,Liu Mei-Feng2,Xiao Wei-Lie1ORCID

Affiliation:

1. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China

2. Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, PR China

Abstract

Wulfenioidins A–C (1–3) with an unusual 6/5-5 spiro tricyclic skeleton were isolated from O. wulfenioides. Compound 3 strikingly inhibited NLRP3 inflammasome activation by blocking the expression of caspase-1, GSDMD-NT, and IL-1β.

Funder

National Natural Science Foundation of China

Applied Basic Research Foundation of Yunnan Province

Program for Changjiang Scholars and Innovative Research Team in University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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