Biswulfenioidins A–E, dioxygen-bridged abietane-type diterpenoid dimers with anti-Zika virus potential from Orthosiphon wulfenioides

Author:

Tu Wen-Chao12,Huang Yong-Xiang3,Kong Yuan-Lin1,Li Bo1,Wang Bin-Bao3,Dong Tian-Hao2,Chen Wei-Chi2,Zeb Muhammad Aurang1,Li Xiao-Li1,Liu Mei-Feng2,Zheng Chang-Bo3,Xiao Wei-Lie14ORCID

Affiliation:

1. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Characteristic Plant Extraction Laboratory; Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy and School of Chemical Science and Technology; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, 650091, People's Republic of China

2. Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, People's Republic of China

3. School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Yunnan Vaccine Laboratory, College of Modern biomedical industry, School of Basic Medical, Kunming Medical University, Kunming, 650500, People's Republic of China

4. Southwest United Graduate School, Kunming, 650592, People's Republic of China

Abstract

Six dioxygen-bridged abietane-type diterpenoid dimers with unprecedented angular fused and rare parallel fused structures were isolated from Orthosiphon wulfenioides. Notably, compounds 5 and 6 showed potent activity against ZIKV by inhibiting the expression of the E and NS5 protein.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

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