Synthesis and spectral characterization of the first fluorescein-tagged iron(ii) clathrochelates, their supramolecular interactions with globular proteins, and cellular uptake

Author:

Selin Roman O.123ORCID,Klemt Insa4567ORCID,Chernii Viktor Ya.123ORCID,Losytskyy Mykhaylo Yu.89103ORCID,Chernii Svitlana89103ORCID,Mular Andrzej11121314ORCID,Gumienna-Kontecka Elzbieta11121314ORCID,Kovalska Vladyslava B.89103ORCID,Voloshin Yan Z.1516171816ORCID,Vologzhanina Anna V.181617ORCID,Dorovatovskii Pavel V.192017ORCID,Mokhir Andriy4567ORCID

Affiliation:

1. Vernadskii Institute of General and Inorganic Chemistry NASU

2. 03080 Kiev

3. Ukraine

4. Organic Chemistry II

5. Friedrich-Alexander-University of Erlangen-Nuremberg

6. 91058 Erlangen

7. Germany

8. Institute of Molecular Biology and Genetics

9. NASU

10. 03143 Kyiv

11. Faculty of Chemistry

12. University of Wroclaw

13. 50-383 Wroclaw

14. Poland

15. Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences

16. 119991 Moscow

17. Russia

18. Nesmeyanov Institute of the Organoelement Compounds of the Russian Academy of Sciences

19. National Research Center Kurchatov Institute

20. 123098 Moscow

Abstract

The fluorescein-tagged iron(ii) clathrochelate was synthesized for the first time and its accumulation in A2780 cancer cells was studied.

Funder

Russian Science Foundation

Russian Foundation for Basic Research

H2020 Marie Skłodowska-Curie Actions

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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