3D-Shaped Binders of Unfolded Proteins Inducing Cancer Cell-Specific Endoplasmic Reticulum Stress In Vitro and In Vivo

Author:

Klemt Insa1,Varzatskii Oleg23,Selin Roman1,Vakarov Serhii23,Kovalska Vladyslava24,Bila Galyna56,Bilyy Rostyslav56ORCID,Voloshin Yan7ORCID,Cuartero Itziar Cossío8,Hidalgo Andrés8,Frey Benjamin9,Becker Ina9,Friedrich Bernhard10,Tietze Rainer10ORCID,Friedrich Ralf P.10,Alexiou Christoph10,Ursu Elena-Laura11,Rotaru Alexandru11,Solymosi Iris1,Pérez-Ojeda M. Eugenia1,Mokhir Andriy1ORCID

Affiliation:

1. Department of Chemistry and Pharmacy, Organic Chemistry II, Friedrich-Alexander-University of Erlangen-Nürnberg (FAU), 91058 Erlangen, Germany

2. Princeton Biomolecular Research Laboratories, 26A Saperne Pole Street, 01042 Kyiv, Ukraine

3. V.I. Vernadsky Institute of General and Inorganic Chemistry, NASU, 32/34 Palladin Av., 03142 Kyiv, Ukraine

4. Institute of Molecular Biology and Genetics, NASU, 150 Zabolotnogo Street, 03143 Kyiv, Ukraine

5. Department of Histology, Cytology and Embryology, Danylo Halytsky Lviv National Medical University, Pekarska Street 69, 79010 Lviv, Ukraine

6. Lectinotest R&D, Mechanichna Street 2, 79024 Lviv, Ukraine

7. Nesmeyanov Institute of Organoelement Compounds, RAS, 28 Vavilova Street, 119334 Moscow, Russia

8. Program of Cardiovascular Regeneration, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), C. Melchor Fernández Almagro, 3, 28029 Madrid, Spain

9. Department of Radiation Oncology, Translational Radiobiology, Universitaetsklinikum Erlangen, Friedrich-Alexander-University of Erlangen-Nürnberg (FAU), Glueckstrasse 4A, 91054 Erlangen, Germany

10. Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), University Hospital, Friedrich-Alexander-University of Erlangen-Nürnberg (FAU), Glückstraße 10a, 91054 Erlangen, Germany

11. “Petru Poni” Institute of Macromolecular Chemistry, Romanian Academy, Centre of Advanced Research in Bionanoconjugates and Biopolymers, Grigore Ghica Voda Alley 41 A, 700487 Iasi, Romania

Funder

European Commission

Ministerio de Ciencia e Innovación

Studienstiftung des Deutschen Volkes

Forschungsstiftung Medizin am Universitätsklinikum Erlangen

Alexander von Humboldt-Stiftung

Friedrich-Alexander-Universität Erlangen-Nürnberg

Manfred Roth Foundation, Fürth

Pro CNIC Foundation

Schmauser- Stiftung

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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