Rationally designed foldameric adjuvants enhance antibiotic efficacy via promoting membrane hyperpolarization-Reference-Cited by-同舟云学术

Rationally designed foldameric adjuvants enhance antibiotic efficacy via promoting membrane hyperpolarization

Published:2022 Issue:1 Volume:7 Page:21-33
ISSN:2058-9689
Container-title:Molecular Systems Design & Engineering
language:en
Short-container-title:Mol. Syst. Des. Eng.

Author:

Bhaumik Kaushik Nath¹,Hetényi Anasztázia¹,Olajos Gábor¹,Martins Ana²^ORCID,Spohn Réka²,Németh Lukács³,Jojart Balázs³,Szili Petra²⁴,Dunai Anett²,Jangir Pramod K.²,Daruka Lejla²⁵,Földesi Imre⁶,Kata Diána⁵,Pál Csaba²,Martinek Tamás A.¹^ORCID

Affiliation:

1. Department of Medical Chemistry, University of Szeged, Dóm tér 8, Szeged HU-6720, Hungary

2. Synthetic and Systems Biology Unit, Biological Research Centre, Eötvös Loránd Research Network (ELKH), Szeged, Hungary

3. Institute of Food Engineering, University of Szeged, Szeged, Hungary

4. Doctoral School of Multidisciplinary Medical Sciences, University of Szeged, Szeged, Hungary

5. Doctoral School of Biology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary

6. Department of Laboratory Medicine, University of Szeged, Szeged, Hungary

Abstract

Antimicrobial foldamers reduce the antibiotic resistance in multi-drug resistant Gram-negative bacteria. They hyperpolarize the membrane at low concentrations by acting as selective ionophores, enhancing the GHK-potential across the membrane.

Funder

H2020 European Research Council

Emberi Eroforrások Minisztériuma

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Industrial and Manufacturing Engineering,Process Chemistry and Technology,Energy Engineering and Power Technology,Biomedical Engineering,Chemical Engineering (miscellaneous),Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2022/ME/D1ME00118C

Reference73 articles.

1. A Protonmotive Force Drives ATP Synthesis in Bacteria

2. Membrane potential is important for bacterial cell division

3. Energy Coupling for Membrane Transport

4. Sensory electrophysiology of bacteria: relationship of the membrane potential to motility and chemotaxis in Bacillus subtilis.

5. Flagella-Driven Motility of Bacteria

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Antibiotics of the future are prone to resistance in Gram-negative pathogens;2023-07-23

2. Recent Approaches for Downplaying Antibiotic Resistance: Molecular Mechanisms;BioMed Research International;2023-01-23

3. Tilted State Population of Antimicrobial Peptide PGLa Is Coupled to the Transmembrane Potential;Journal of Chemical Information and Modeling;2022-10-03

4. Helical Foldamers and Stapled Peptides as New Modalities in Drug Discovery: Modulators of Protein-Protein Interactions;Processes;2022-05-06

5. Gold nanocluster adjuvant enables the eradication of persister cells by antibiotics and abolishes the emergence of resistance;Nanoscale;2022