Gold nanocluster adjuvant enables the eradication of persister cells by antibiotics and abolishes the emergence of resistance-Reference-Cited by-同舟云学术

Gold nanocluster adjuvant enables the eradication of persister cells by antibiotics and abolishes the emergence of resistance

Published:2022 Issue:28 Volume:14 Page:10016-10032
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Cao Zhixin¹²,Chen Xiaohua¹³,Chen Jing¹,Xia Anping¹,Bacacao Brian¹,Tran Jessica⁴,Sharma Devesh¹,Bekale Laurent A.¹^ORCID,Santa Maria Peter L.¹

Affiliation:

1. Department of Otolaryngology, Head and Neck Surgery, Stanford University, 801 Welch Road, Stanford, CA 94305-5739, USA

2. Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, China

3. Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450000, China

4. The Protein and Nucleic Acid Biotechnology Facility, Beckman Center Stanford University, 279 Campus Drive, West Stanford, CA 94305, USA

Abstract

Anionic AuNC@CPP enters the cells and dissipates the proton gradient (ΔpH), which is compensated by an increase in electrical potential (ΔΨ) that leads to membrane hyperpolarization and enhances the susceptibility of persisters to antibiotics.

Funder

Natural Science Foundation of Shandong Province

Health Commission of Henan Province

National Institutes of Health

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Stanford Maternal and Child Health Research Institute

Stanford University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NR/D2NR01003H

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