Abstract
A “foldamer” is an artificial oligomeric molecule with a regular secondary or tertiary structure consisting of various building blocks. A “stapled peptide” is a peptide with stabilized secondary structures, in particular, helical structures by intramolecular covalent side-chain cross-linking. Helical foldamers and stapled peptides are potential drug candidates that can target protein-protein interactions because they enable multipoint molecular recognition, which is difficult to achieve with low-molecular-weight compounds. This mini-review describes a variety of peptide-based foldamers and stapled peptides with a view to their applications in drug discovery, including our recent progress.
Funder
Japan Agency for Medical Research and Development
Japan Society for the Promotion of Science
Takeda Science Foundation
Naito Foundation
Sumitomo Foundation
Novartis Foundation (Japan) for the Promotion of Science
Foundation for Promotion of Cancer Research in Japan
Subject
Process Chemistry and Technology,Chemical Engineering (miscellaneous),Bioengineering
Cited by
8 articles.
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