Design and organocatalytic synthesis of spirooxindole–cyclopentene–isoxazole hybrids as novel MDM2

Design and organocatalytic synthesis of spirooxindole–cyclopentene–isoxazole hybrids as novel MDM2–p53 inhibitors

Published:2021 Issue:8 Volume:8 Page:1836-1843
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Xie Xin¹²³⁴⁵,Xiong Shan-Shan⁶⁷⁸⁹⁵,Li Xiang¹²³⁴⁵,Huang He¹²³⁴⁵,Wu Feng-Bo¹²³⁴⁵^ORCID,Shen Peng-Fei⁶⁷⁸⁹⁵,Peng Cheng¹²³⁴⁵^ORCID,He Gu⁶⁷⁸⁹⁵^ORCID,Han Bo¹²³⁴⁵^ORCID

Affiliation:

1. College of Medical Technology and School of Pharmacy

2. State Key Laboratory of Southwestern Chinese Medicine Resources

3. Chengdu University of Traditional Chinese Medicine

4. Chengdu 611137

5. China

6. State Key Laboratory of Biotherapy and Department of Pharmacy

7. West China Hospital

8. Sichuan University

9. Chengdu

Abstract

An organocatalytic 1,6-cycloaddition with exclusive α-regioselectivity to synthesize designed spirooxindole–cyclopentene–isoxazole hybrids as novel MDM2–p53 inhibitors.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Chengdu University of Traditional Chinese Medicine

Department of Science and Technology of Sichuan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/QO/D0QO01626H

Reference78 articles.