Environment-sensitive turn-on fluorescent probes for p53–MDM2 protein–protein interaction-Reference-Cited by-同舟云学术

Environment-sensitive turn-on fluorescent probes for p53–MDM2 protein–protein interaction

Published:2017 Issue:8 Volume:8 Page:1668-1672
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Liu Tingting¹²³⁴⁵,Jiang Yan¹³⁶⁷⁸,Liu Zhenzhen¹²³⁴⁵,Li Jin¹³⁶⁷⁸,Fang Kun¹³⁶⁷⁸,Zhuang Chunlin¹³⁶⁷⁸,Du Lupei¹²³⁴⁵,Fang Hao¹²³⁴⁵,Sheng Chunquan¹³⁶⁷⁸,Li Minyong¹²³⁴⁵^ORCID

Affiliation:

1. Department of Medicinal Chemistry

2. Key Laboratory of Chemical Biology (MOE)

3. School of Pharmacy

4. Shandong University

5. Jinan

6. Second Military Medical University

7. Shanghai 200433

8. China

Abstract

A series of small-molecule fluorescent probes were designed and synthesized for detecting and imaging p53–MDM2 interaction in the human lung cancer cell line A549.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C7MD00287D

Reference28 articles.

1. p53, the Cellular Gatekeeper for Growth and Division

2. Surfing the p53 network

3. MDMX: a novel p53-binding protein with some functional properties of MDM2.

4. The p53-mdm-2 autoregulatory feedback loop.

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