Enantioselective synthesis of unsymmetrical α,α-diarylacetates <i>via</i> organocatalyzed formal C–H insertion reactions of sulfoxonium ylides with indoles and pyrroles-Reference-Cited by-同舟云学术

Enantioselective synthesis of unsymmetrical α,α-diarylacetates via organocatalyzed formal C–H insertion reactions of sulfoxonium ylides with indoles and pyrroles

Published:2024 Issue:15 Volume:11 Page:4084-4093
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Yue Xin¹,Li Shi-Jia²,Ou Tianyuan¹,Xiong Zhenying¹,Jiang Feng¹,Zhou Ying¹,Song Lijuan³^ORCID,Zhao Yupei¹^ORCID,Guo Wengang¹^ORCID

Affiliation:

1. School of Petrochemical Engineering, Changzhou University, Changzhou, Jiangsu 213164, P. R. China

2. Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon 999077, Hong Kong SAR, P. R. China

3. School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, P. R. China

Abstract

A chiral phosphoric acid-catalyzed highly enantioselective formal C–H insertion reaction of N–H free indole and pyrrole with sulfoxonium ylides has been developed (up to 95% yield and 97% ee).

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D4QO00753K

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