Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (nN → σ*S–X) Interaction for Conformational Constraint-Reference-Cited by-同舟云学术

Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (nN → σ*S–X) Interaction for Conformational Constraint

Published:2015-12-01 Issue:24 Volume:58 Page:9663-9679
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pennington Lewis D.¹,Bartberger Michael D.¹,Croghan Michael D.¹,Andrews Kristin L.¹,Ashton Kate S.¹,Bourbeau Matthew P.¹,Chen Jie¹,Chmait Samer¹,Cupples Rod¹,Fotsch Christopher¹,Helmering Joan¹,Hong Fang-Tsao¹,Hungate Randall W.¹,Jordan Steven R.¹,Kong Ke¹,Liu Longbin¹,Michelsen Klaus¹,Moyer Carolyn¹,Nishimura Nobuko¹,Norman Mark H.¹,Reichelt Andreas¹,Siegmund Aaron C.¹,Sivits Glenn¹,Tadesse Seifu¹,Tegley Christopher M.¹,Van Gwyneth¹,Yang Kevin C.¹,Yao Guomin¹,Zhang Jiandong¹,Lloyd David J.¹,Hale Clarence¹,St. Jean David J.¹

Affiliation:

1. Medicinal Chemistry, ‡Molecular Structure and Characterization, §Pharmacokinetics and Drug Metabolism, ∥Metabolic Disorders Research, and ⊥Pathology, Amgen, One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States

Funder

U.S. Department of Energy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5b01367

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