The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators-Reference-Cited by-同舟云学术

The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators

Published:2019-05-03 Issue:10 Volume:62 Page:5049-5062
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tseng Chih-Chung¹,Baillie Gemma²,Donvito Giulia,Mustafa Mohammed A.,Juola Sophie E.,Zanato Chiara¹,Massarenti Chiara¹,Dall’Angelo Sergio¹,Harrison William T. A.³^ORCID,Lichtman Aron H.,Ross Ruth A.²,Zanda Matteo¹⁴^ORCID,Greig Iain R.¹

Affiliation:

1. Kosterlitz Centre for Therapeutics, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD Scotland, U.K.

2. Department of Pharmacology & Toxicology, University of Toronto, Toronto M5S 1A8, Canada

3. Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen, AB24 3UE Scotland, U.K.

4. C.N.R. − I.C.R.M., via Mancinelli 7, 20131 Milan, Italy

Funder

Canadian Institutes of Health Research

National Institute on Drug Abuse

School of Pharmacy, Virginia Commonwealth University

Signal Pharma, University of Aberdeen

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00252

Reference36 articles.

1. Allosteric modulators of cannabinoid receptor 1: developing compounds for improved specificity

2. The future of type 1 cannabinoid receptor allosteric ligands

3. Adam, L.; Rihakova, L.; Lapointe, S.; St-Onge, S.; Labrecque, J.; Payza, K. Positive Allosteric Modulators of CB1 Receptors. In 17th Annual Symposium on the Cannabinoids; Poster 86; Saint-Sauveur, Québec, Canada. Abstract available from http://icrs.co/SYMPOSIUM.2007/2007.ICRS.Program.and.Abstracts.pdf, 2007. Accessed on March 26 2019, 2007.

4. Crystal structures of four indole derivatives as possible cannabinoid allosteric antagonists

5. Enantiospecific Allosteric Modulation of Cannabinoid 1 Receptor

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