A copper-catalyzed annulation reaction of diazo esters with propargyl amines for the synthesis of 2,5-dihydropyrroles-Reference-Cited by-同舟云学术

A copper-catalyzed annulation reaction of diazo esters with propargyl amines for the synthesis of 2,5-dihydropyrroles

Published:2024 Issue:16 Volume:11 Page:4546-4555
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Xie Haodong¹,Zhao Wei²,Wei Heping²,Yu Yang³^ORCID,Zhao Lili⁴^ORCID,Baell Jonathan B.¹,Huang Fei¹^ORCID

Affiliation:

1. School of Pharmaceutical Science, Nanjing Tech University, Nanjing 211816, P. R. China

2. School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, P. R. China

3. School of Environmental Science and Engineering, Nanjing Tech University, Nanjing 211816, P. R. China

4. Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, P. R. China

Abstract

An efficient protocol for the synthesis of 2,5-dihydropyrroles using diazo esters and propargyl amines has been reported, featuring mild reaction conditions, straightforward operation, the absence of metal ligands, and high atom economy.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D4QO00751D

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