Structure–Activity Relationship Studies of Tolfenpyrad Reveal Subnanomolar Inhibitors of Haemonchus contortus Development

Author:

Le Thuy G.1,Kundu Abhijit2,Ghoshal Atanu2,Nguyen Nghi H.1,Preston Sarah34,Jiao Yaqing3,Ruan Banfeng15,Xue Lian6,Huang Fei6ORCID,Keiser Jennifer78ORCID,Hofmann Andreas9ORCID,Chang Bill C. H.3,Garcia-Bustos Jose3,Wells Timothy N. C.10,Palmer Michael J.10,Jabbar Abdul3,Gasser Robin B.3,Baell Jonathan B.61ORCID

Affiliation:

1. Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Melbourne, Victoria 3052, Australia

2. TCG Lifesciences Private Limited, Block BN, Plot 7, Salt-Lake Electronics Complex, Sector V, Kolkata 700091, West Bengal, India

3. Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia

4. School of Health and Life Sciences, Federation University, Ballarat, Victoria 3353, Australia

5. School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, P. R. China

6. School of Pharmaceutical Sciences, Nanjing Tech University, No. 30, South Puzhu Road, Nanjing 211816, P. R. China

7. Swiss Tropical and Public Health Institute, 4051 Basel, Switzerland

8. University of Basel, 4001 Basel, Switzerland

9. Griffith Institute for Drug Discovery, Griffith University, Nathan, Brisbane, Queensland 4111, Australia

10. Medicines for Malaria Venture, 1215 Geneva 15, Switzerland

Funder

National Health and Medical Research Council

Australian Research Council

Medicines for Malaria Venture

Yourgene Bioscience

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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