Toward a Rationale for the PTC124 (Ataluren) Promoted Readthrough of Premature Stop Codons: A Computational Approach and GFP-Reporter Cell-Based Assay-Reference-Cited by-同舟云学术

Toward a Rationale for the PTC124 (Ataluren) Promoted Readthrough of Premature Stop Codons: A Computational Approach and GFP-Reporter Cell-Based Assay

Published:2014-02-07 Issue:3 Volume:11 Page:653-664
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Lentini Laura¹,Melfi Raffaella¹,Di Leonardo Aldo¹²,Spinello Angelo¹,Barone Giampaolo¹³,Pace Andrea¹³,Palumbo Piccionello Antonio¹,Pibiri Ivana¹

Affiliation:

1. Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche, Università degli Studi di Palermo, Viale delle Scienze Ed. 17, 90128 Palermo, Italy

2. Centro di OncoBiologia Sperimentale (COBS), via San Lorenzo Colli, 90145 Palermo, Italy

3. Istituto EuroMediterraneo di Scienza e Tecnologia (IEMEST), Via Emerico Amari 123, 90139 Palermo, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/mp400230s

Reference72 articles.

1. Nonsense-mediated mRNA decay: terminating erroneous gene expression

2. Nonsense-mediated mRNA decay in mammals

3. When the Message Goes Awry